Mr. T Posted November 4, 2009 Report Share Posted November 4, 2009 US Patent Application 20090010962 - Genetically Engineered Swine Influenza Virus and Uses Thereof Abstract text The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swine influenza viruses having modifications to a swine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations. Here it is! Who stands to profit? Link to comment Share on other sites More sharing options...
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